Path of Exile 2: All Anomaly Bosses and How to Clear Them

Anomaly bosses in Path of Exile 2 have quickly become some of the most challenging and rewarding encounters in the game. Introduced in patch 0.3, these bosses drop exclusive Lineage Support Gems that are highly sought after for endgame builds. As of now, there are four Anomaly bosses, all tied to final encounters from Act 4 and the three Interludes. This guide covers all Anomaly bosses, how to locate them, strategies to defeat them, and the unique rewards you can earn.

What Are Anomaly Bosses in Path of Exile 2?

Anomaly bosses are endgame-focused encounters that require players to complete the main campaign and explore the Atlas. Each boss presents multi-phase fights with unique mechanics, combining high-damage attacks, AoE patterns, and mobility challenges. Unlike standard bosses, these fights test both strategy and skill, making them rewarding for dedicated players.

These bosses drop rare and exclusive items, including Lineage Support Gems, making them crucial for competitive builds. Farming these bosses efficiently can dramatically improve your character's power and versatility.

All Anomaly Bosses in Path of Exile 2

1) Manoki, the Chosen

·Location: Jade Isle (Endgame Atlas)

·Inspired by: Tavakai, Karui Chieftain (Act 4)

·Access Requirements: Remove Maelstrom by clearing connected maps and disabling a Karui Beacon.

Manoki is a three-phase encounter:

·Phase One: Manoki appears in semi-human form. Reduce his HP by 60% to trigger a transformation, and HP reset near Tukohama's shrine. Watch for slam attacks.

·Phase Two: The boss uses corrupted attacks and spikes from the ground. A short delay allows dodging, but hitting full damage quickly is essential.

·Phase Three: Increased speed and AoE attacks. Prolonged fights risk a DoT ground attack that drains life flasks.

Possible Rewards: Kaom's Madness, Rakiata's Flow, Tawhoa's Tending, Tasalio's Rhythm.

Tips: Maintain mobility, use ranged or dodging skills to avoid spikes, and burst him down before the arena becomes overwhelming.

2) Varloch, the Ashen Lord, and Avelyne, the Withered Rose

·Location: Derelict Mansion (Atlas Node)

·Inspired by: Interlude 1 - Curse of Holten

·Access Requirements: Activate Draiocht Hengestones in connected maps.

This fight is dual-boss combat:

·Varloch: Uses sword slams and shockwaves; timing and positioning are key.

·Avelyne: Summons Bone Cages and orbital strikes. Break cages quickly and avoid AoE damage.

Possible Rewards: Rigwald's Ferocity, Ailith's Chimes, Einhar's Beastrite.

Tips: Focus on one boss at a time and manage AoE attacks carefully. Efficient farming of Path of Exile 2 Items from this boss is possible, and if needed, players can buy POE2 Currency to enhance gear before attempting these fights.

3) Zahmir, the Blade Sovereign

·Location: Sacred Reservoir (Atlas Node)

·Inspired by: Azmadi, Faridun Prince (Interlude 2)

·Access Requirements: Disable three Temporal Tethers across connected desert maps.

Two-Phase Fight:

·Phase One: Zahmir's attacks come in combos and can stagger your character. Lower HP by 40% before he enters phase two.

·Phase Two: Supercharged with additional combos and time-related attacks. Curving attacks make dodging tricky; do not let him move off-screen.

Possible Rewards: Varashta's Blessing, Khatal's Rejuvenation, Zarokh's Refrain, Garukhan's Resolve.

Tips: Focus on mobility and dodging combos. Use terrain or obstacles to reduce exposure and prepare for sudden supercharged attacks.

4) Ytzara, Blood Oracle, and Maztli, Flesh-Shaper

·Location: Estazunti's Vault (Atlas Node)

·Inspired by: Interlude 3 - Vaal sibling duo

·Access Requirements: Spawn via floating pillar after defeating the connected map boss (patch 0.4 update).

Fight Mechanics:

·Claw Attack: Leech life from the sister; dodge carefully.

·Corrupted Beam: Brother performs a laser attack; avoid it using cover or distance.

·Goliath Slam: Brother transforms and performs AoE slam; maintain safe distance.

·Possible Rewards: Atalui's Bloodletting, Tacati's Ire, Paquate's Pact.

Tips: Focus on one boss at a time if possible. Avoid prolonged exposure to leech attacks, and ensure your team manages positioning to mitigate AoE damage.

General Strategies for Anomaly Bosses

1. Use Precursor Tablets to empower bosses for higher loot quality.

2. Tier 15 Waystones increase item rarity and drop chance.

3. Avoid dying: Losing all revives results in loss of map rewards.

4. Coordinate crowd control and positioning: Especially critical for dual-boss fights like Varloch and Avelyne.

5. Understand attack patterns: All Anomaly bosses have predictable yet deadly attacks that can be exploited with careful timing.

Conclusion

Anomaly bosses in Path of Exile 2 are a core part of the endgame, offering both challenge and reward. From Manoki's multi-phase chaos to the Vaal sibling duo, each fight requires a combination of skill, strategy, and preparation. Efficient farming of these bosses yields exclusive Lineage Support Gems and powerful unique items, essential for crafting competitive endgame builds.

Mastering these bosses not only enhances your gear but also sharpens your gameplay, making your character unstoppable in both Atlas exploration and high-tier endgame content. By following this guide, you'll be well-prepared to tackle all four Anomaly bosses in Path of Exile 2.